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Age-related characteristics of the metabolism of fatty acid components of nuclear phospholipids

Nikitin, V.N.; Babenko, N.A.; Popova, L.I.; Petruniaka, V.V.

Biokhimiia 51(10): 1714-1717

1986

ISSN/ISBN: 0320-9725
PMID: 3778974
Document Number: 274241
The metabolism of liver nuclear phospholipid acyl components of rats of various age was studied in vitro. It was found that the activity of phospholipases A1 and A2 in the nuclei sharply increased in animals aged 1-3 months, showing a decrease in 12- and 24-month-old animals. The incorporation of labeled arachidonic acid into nuclear phospholipids remained practically unchanged thereby. The age-specific fluctuations in the activity of nuclear phospholipids A1 and A2 may be one of possible reasons of changes in the fatty acid composition of nuclear lipids during ontogenesis.

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