Influence of different carbon dioxide concentrations on protein, lipid and nucleic acid metabolism in rat liver
Lutsenko, N.I.; Silonova, N.V.; Mel'nichuk, D.A.; Gulyĭ, M.F.
Ukrains'kyi Biokhimichnyi Zhurnal 49(2): 58-62
1977
ISSN/ISBN: 0041-610X PMID: 867539 Document Number: 121343
When the content of carbonic acid in the incubation media increases from 10 up to 40 mM at pH 7.2, 7.4 and 7.6, incorporation of 14C into lipids is twice as high due to such precursors as glycine-2-14C, acetate-2-14C and valine-1-14C. A stimulating effect of carbonic acid high concentrations on the intensity of 14C incorporation from the mentioned precursors into proteins and from glycine-2-14C into RNA is observed at all the studied values of pH of the incubation medium, whereas the same activation with respect to DNA is the most pronounced at pH 7.2 and 7.6.