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Morphogenesis of thymus involution during oxythiamine B1-hypovitaminosis

Kovalevskiĭ, G.V.; Skriabina, G.A.

Biulleten' Eksperimental'noi Biologii i Meditsiny 91(6): 727-730

1981

ISSN/ISBN: 0365-9615
PMID: 6974019
Document Number: 172898
Atrophy of the thymus cortex was found in rats after administration of oxythiamine. In acute experiments, atrophy was a consequence of a short-term inhibition of proliferation followed by enhancement of disintegration of small thymocytes by caryorhexis. Disintegration assumes an exceptional significance for thymus involution. Breakdown of cells correlated with a sharp decrease in thymocyte resistance to hydrocortisone. Possible metabolic reasons for the decreased resistance are discussed.

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