Antivitamin activity of oxythiamine disulfide nicotinate
Oparin, D.A.; Zabrodskaia, S.V.
Ukrainskii Biokhimicheskii Zhurnal 64(2): 102-104
1992
ISSN/ISBN: 0201-8470 PMID: 1413106 Document Number: 395061
The B1-antivitamin activity of oxythiamine disulphide nicotinate has been determined in experiments on albino mice and it is shown that in the liver this derivative exerts the equal action while in the blood and heart--a more profound and prolonged inhibitory action on the transketolase activity in comparison with oxythiamine disulphide. Like the initial compound oxythiamine disulphide nicotinate does not penetrate through hemato-encephalic barrier and does not inhibit the brain transketolase.