Comparative antivitamin activity of oxythiamine disulfide and its monosulfoxide
Zimatkina, T.I.; Oparin, D.A.
Ukrainskii Biokhimicheskii Zhurnal 62(3): 77-80
1990
ISSN/ISBN: 0201-8470 PMID: 2396324 Document Number: 354697
The B1-antivitamin activity of oxythiamine disulphide monosulphoxide has been determined in experiments on albino mice. It is shown that this derivative is less toxic and exerts a more profound and prolonged inhibitory action on the pyruvate dehydrogenase and transketolase activity in the animal body in comparison with initial oxythiamine disulphide.
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