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The production of immunomodulating polypeptides by the thymus during its acute (accidental) involution in children

Zaĭrat'iants, O.V.; Khavinson, K.V.; Kuz'menko, L.G.

Arkhiv Patologii 52(1): 25-28

1990

ISSN/ISBN: 0004-1955
PMID: 2337389
Document Number: 362274
The content of the thymalin polypeptides in the thymus is studied in the course of the 1st to 4th stages of the acute thymus involution in children dying from noninfectious and infectious disease. The results obtained were compared to the level of the circulating thymic factor and the number of T- and 'O' lymphocytes in the circulating blood of children with identical diseases and control group of the same age. It is concluded that the acute involution of the thymus in children with non-infectious and acute infectious diseases results in the progressive decrease of the production by the thymus of the immunomodulating polypeptides (thymic hormones) which is restored in the period of recovery.

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