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Neuroendocrine effect of thyroliberin and its analogs

Babichev, V.N.; Samsonova, V.M.; Airapetiants, M.G.; Kolomeĭtseva, I.A.; Shvachkin, I.P.

Problemy Endokrinologii 27(4): 35-38

1981

ISSN/ISBN: 0375-9660
PMID: 6794024
Document Number: 170274
In experiments on rats, thyroliberin (TRH) and its analogue pyroglutamyl-histidyl-prolinamide stimulating effects on the CNS were shown. They produced a decrease in some phases of the sleep duration (particularly, in the deep one) and augmented the awakening period. At the same time, the antagonistic effect of these compounds with respect to nembutal anaesthesia was seen. On the contrary, TRH analogue pyroglutamyl-seryl-glycinamide decreased the awakening time and prolonged some phases of the sleep, not exerting antagonistic action on nembutal toxic effect. Both TRH analogues did not influence TTH secretion.

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