Neuroendocrine factors in pathogenesis of motion sickness and the protective effect of drugs
Shashkov, A.V.; Karsanova, S.K.; Iasnetsov, V.V.; Tigranian, R.A.; Shashkov, V.S.
Eksperimental'naia i Klinicheskaia Farmakologiia 67(2): 3-7
2004
ISSN/ISBN: 0869-2092 PMID: 15188750 Document Number: 572444
The paper presents a generalization of many-year complex investigations performed at various departments of the Institute of Medico-Biological Problems (Moscow) and various laboratories and institutes of the Ministry of Public Health and the Russian Academy of Medical Sciences, devoted to the pathogenesis of motion disease (sea sickness, vestibulo vegetative syndrome, various forms of kinetosis). The main attention is given to interpretation of the mechanisms of therapeutic and prophylactic action of drugs used for the treatment of such disorders. In particular, the role of a hormonal component of the system of regulation of physiological functions is considered as manifested in the models of the vestibulovegetative syndrome and in the pharmacotherapy of the motion disease.