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Antihypoxic effect of analogs of cyclic adenosine monophosphate, phosphodiesterase inhibitors

Kozhemiakin, L.A.; Korostovtsev, D.S.; Koroleva, T.R.

Farmakologiia i Toksikologiia 41(6): 711-714

1978

ISSN/ISBN: 0014-8318
PMID: 214339
Document Number: 124839
A number of investigated cAMP derivatives are shown to inhibit the cAMP-phosphodiesterase in brain tissues of white rats in vitro. The 8-substituted aminoethylamino-derivatives proved to be effective inhibitors of the enzyme. Among them the most pronounced inhibition displayed the 8-(beta-aminoethylamino)-cAMP. In an in vitro experiment on the model of hypoxic hypoxia in rats it was shown to possess strong anti-hypoxic properties. The possible prospective clinical use of the cAMP analogs--inhibitors of the cAMP-phosphodiesterase--is discussed.

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