Membrane permeability to aminazine and nonachlazine
Dobretsov, G.E.; Spirin, M.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 90(9): 311-313
1980
ISSN/ISBN: 0365-9615 PMID: 7426733 Document Number: 166770
Model phospholipid vesicles (liposomes) and the fluorescent probe p-terphenyl were used to study membrane permeability by phenothiazine anesthetics. The anesthetics quenched the fluorescence of the probe bound to the membrane. The extent of the quenching depended on the quenching ability to penetrate the lipid bilayer. Aminazine was able to penetrate the lipid bilayer, while nonachlazine was not. This may be accounted for by the presence of 2 N atoms capable of binding to H+ in the nonachlazine molecule in contrast to 1 N atom in the aminazine molecule.