The effect of mildronate on erythrocyte membrane permeability in experimental lung pathology
Antonenko, L.I.; Frantsuzova, S.B.; Arshinnikova, L.L.
Eksperimental'naia i Klinicheskaia Farmakologiia 55(6): 33-35
1992
ISSN/ISBN: 0869-2092 PMID: 1305872 Document Number: 399390
With the use of the erythrocyte osmotic and acidic resistance methods, the experiments on intact albino rats by applying a model of chronic non-specific lung diseases and those in vitro have shown that mildronate has a membrane-stabilizing action only when given in high doses (500 mg/kg) and concentrations (10(-3)-10(-4) M). When used in low doses (5, 25, 50, and 200 mg/kg) and concentrations (10(-5)-10(-7) M), in produces no positive effect.