Erythrocyte membrane proteins in experimental D-hypovitaminosis
Nikiforova, T.N.; Apukhovskaia, L.I.; Ivashkevich, S.P.
Voprosy Meditsinskoi Khimii 34(3): 30-34
1988
ISSN/ISBN: 0042-8809 PMID: 3420806 Document Number: 323838
Content of rat erythrocyte membrane proteins was studied in experimental rickets as well as during treatment of the disease with various doses of vitamin D3. Distinct alterations in content of spectrin and protein 3 simultaneously with approximately constant level of membrane total proteins were observed in D-hypovitaminosis. Composition of main membrane proteins tended to be normalized after administration of vitamin D3 (400 IU) into the animals with experimental rickets within 10 days, while the vitamin at a dose exceeding 100-fold the physiological requirements, caused a decrease in the content of membrane proteins. Alterations in molecular structure of erythrocyte membranes appear to be among the factors responsible for inhibition of erythrocyte functional activity in rickets.