Contents of the main erythrocyte membrane proteins in patients with primary arterial hypertension and its relationship with hereditary predisposition to cardiovascular diseases
Ivanov, V.P.; Polonikov, A.V.; Solodilova, M.A.; Lukashov, A.A.
Terapevticheskii Arkhiv 72(9): 73-76
2000
ISSN/ISBN: 0040-3660 PMID: 11076426 Document Number: 518129
To study quantitative content of main erythrocyte membrane proteins in patients with primary arterial hypotension and its relationship with hereditary predisposition to cardiovascular disease. Quantitative content of main erythrocyte membrane proteins in 109 patients with primary arterial hypotension (PAH) and 124 healthy persons was measured with unidimensional polyacrylamide gel electrophoresis. Hereditary determination of PAH was studied by the clinical-genealogical method. PAH patients showed quantitative alterations in erythrocyte membrane protein composition: increased content of alpha-spectrin, ankyrin (band 2.1), anion exchange protein (band 3) and decreased content of actin, tropomyosin and glutathione-S-transferase. Patients with aggravated heredity for PAH had higher content of beta-spectrin and ankyrin (band 2.1 and 2.2) then patients without aggravated heredity for PAH. Quantitative alterations of membrane proteins in patients with PAH could significantly modify the structure of cytoskeleton and result in modification of the enzyme activity of transmembrane proteins (ATPases) regulating cation transport across erythrocyte membrane. Moreover, aggravated heredity for PAH predisposes to high content of cytoskeletal proteins (beta-spectrin, 2.1 and 2.2 ankyrin) which could form more compact structure of erythrocyte membrane and limit cation influx into cytoplasma.