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Influence of cationic cyclopeptide on microstructure and permeability of Caco-2 cell membrane

Li, X.-H.; Chang, M.-M.; Wang, Q.; Sun, Y.-M.; Liu, Y.

Yao Xue Xue Bao 49(7): 1062-1068

2014

ISSN/ISBN: 0513-4870
PMID: 25233641
Document Number: 672962
The microstructure of cationic cyclopeptide (TD-34) treated Caco-2 cell membrane was observed, and we discussed the relationship between membrane structure and insulin transmembrane permeability. Atomic force microscope (AFM) was used to observe living cell membrane in air condition and tapping mode. Results showed that the surface of Caco-2 cell membrane treated with TD-34 lost its smoothness and nearly doubled its roughness. Apparent permeability coefficients (P(app)) of insulin in Caco-2 cell monolayers increased 2.5 times. In conclusion, AFM can be used to observe microstructure of cationic cyclopeptide treated cell membrane and cationic cyclopeptide enhanced insulin delivery across Caco-2 cell membrane by increasing membrane fluidity.

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