The protective effect of serotonin against the depolarizing influence of aminazine on the membrane potentials of mouse embryos, in vitro, at the 2-blastomere stage
Leonov, B.V.; Limantsev, A.V.; Persianinov, L.S.
Biulleten' Eksperimental'noi Biologii i Meditsiny 79(1): 41-43
1975
ISSN/ISBN: 0365-9615 PMID: 1111643 Document Number: 91710
The action of chlorpromazine, serotonin and prostaglandin F2-alpha on the cellular membrane potential of 2-cell mouse embryos, as well as a protective effect of serotonin and prostaglandin F2-alpha against the inhibition of the membrane potential by chlorpromazine were studied. Chlorporomazine (1.10-5 g/ml) proved to induce a strong decrease of the membrane potential, but serotonin, prostaglandin F2-alpha were ineffective. Serotonin (1.10-4 g/ml) prevented the action of chlorpormazine (2.10-6 g/ml), whereas prostaglandin F2-alpha (4-8.10-6 g/ml) was ineffective in this respect.