Therapeutic efficacy of oral oxamniquine in the toxemic form of schistosomiasis mansoni: treatment of eleven individuals from two families, and experimental study
Lambertucci, J.R.; Pedroso, E.R.; de Souza, D.W.; de Lima, D.P.; Neves, J.; Salazar, H.M.; Marinho, R.P.; da Costa Rocha, M.O.; Coelho, P.M.; de Lima Costa, M.F.; Greco, D.B.
American Journal of Tropical Medicine and Hygiene 29(1): 50-53
1980
ISSN/ISBN: 0002-9637 PMID: 7352627 Document Number: 164510
Two families of 6 and 5 individuals in Belo Horizonte, Brazil, became acutely infected with Schistosoma mansoni. Symptoms developed 20 to 60 days after exposure. The patients were treated at 55 and 77 days respectively after infection with a single oral dose of oxamniquine 20 mg/kg body-weight. Parasitological cure was obtained in 5 patients (45%) and the numbers of ova in the faeces of the other 6 patients were significantly reduced. These patients were treated again 10 months later and they were cured. No side effects were observed. Mice infected with strains from 3 of these patients were cured by a single dose of oxamniquine 100 mg/kg by mouth.