Experimental challenge of dogs with canine parvovirus-2
Carman, P.S.; Povey, R.C.
Veterinary Record 107(19): 447
1980
ISSN/ISBN: 0042-4900 PMID: 7456298 Document Number: 158843
Twenty-four, 3-month-old puppies which had been deprived of food 24 h before and 48 h after receiving an oral dose of 10 ml of gut mucosal scrapings collected from a dog previously infected with canine parvovirus-2 (CPV-2) showed symptoms of the disease. Virus was recovered from faeces of all dogs with the greatest concentration occurring 6-7 days after exposure. Other experiments in which the same inoculum was used in dogs which were not starved failed to produce clinical signs despite causing positive CPV-2 seroconversion. It is suggested that starvation may depress the rate of cell turnover in the intestine which may be followed, when feeding is restored, by an increase in mitotic activity which is important to parvovirus replication and virulence.