Experimental parvovirus infection of puppies: immunohistological findings
Vlemmas, I.; Wohlsein, P.; Trautwein, G.; Kanakudis, G.; Tsangaris, T.
Berliner und Munchener Tierarztliche Wochenschrift 103(12): 422-425
1990
ISSN/ISBN: 0005-9366 PMID: 1964045 Document Number: 358346
Formalin-fixed tissue samples obtained from puppies experimentally infected with canine parvovirus type 2 (CPV-2) were investigated immunohistologically with the direct immunoperoxidase method. Besides cardiac muscle and lymphatic tissues, bone marrow, intestine, liver, kidney, pancreas and to a lesser degree lung stained positive for viral antigen and are considered as sites of viral replication. The distribution of viral antigen reveals a tropism of CPV-2 to numerous organs in puppies infected during the first week of life.