Canine parvovirus infection potentiates canine distemper encephalitis attributable to modified live-virus vaccine
Krakowka, S.; Olsen, R.G.; Axthelm, M.K.; Rice, J.; Winters, K.
Journal of the American Veterinary Medical Association 180(2): 137-139
1982
ISSN/ISBN: 0003-1488 PMID: 7061309 Document Number: 184446
Twelve gnotobiotic dogs from two litters were allotted to three groups. Group A dogs received a modified-live polyvalent (canine distemper, adenovirus type 2, and parainfluenza viruses and Leptospira canicola-icterohemorrhagiae bacterin) vaccine three days prior to oral inoculation with canine parvovirus (CPV). Group B dogs received CPV alone. Group C dogs received one dose of vaccine only. In none of the 9 CPV-inoculated dogs did clinical signs of CPV infection develop, although high serum antibody titres for CPV developed in all of them. Distemper encephalomyelitis subsequently deveoped in 2 of the 5 CPV-inoculated vaccinated dogs. Hence CPV can alter the canine immune response, and may be responsible for vaccination failures in dogs.