Hepatic lesions caused by vinyl chloride monomer in humans. Study of eight clinicopathological cases
Pialat, J.; Pasquier, B.; Pahn, M.; Kopp, N.
La Semaine des Hopitaux Organe Fonde Par l'Association d'Enseignement Medical des Hopitaux de Paris 56(25-28): 1188-1202
1980
ISSN/ISBN: 0037-1777 PMID: 6256869 Document Number: 156356
Six hepatic angiosarcomas, one hepatoma and one hepatic "fibrosis" with portal hypertension in patients chronically exposed to vinyl chloride monomer (VCM) are reported. The industrial methods of synthesis and current knowledge concerning the carcinogenic role of VCM are reviewed. Histogenetic and pathogenetic concepts of "fibrosis" and angiosarcomas of liver are exposed.