Pharmacokinetics of a new hypoglycemic agent SPC-703
Jakubowski, Z.; Angielski, S.
Polish Journal of Pharmacology and Pharmacy 32(2): 165-172
1980
ISSN/ISBN: 0301-0244 PMID: 7454622 Document Number: 156357
Pharmacokinetic of a new hypoglycemic agent, SPC-703 was studied in rats after iv, ip and po administration of two doses of the drug. It was found that biological half-time (t 1/2) did not depend upon the route of administration, t 1/2 value was 12.5-13.8 hr. There was no statistically significant difference in the pharmacokinetic parameters of SPC-703 after administration of two doses, 25 and 50 mg/kg of the drug. The volume of distribution of the unbound to serum protein SPC-703 was 93 ml, the volume of distribution assayed for the total amount of SPC-703 was 42.4 ml. SPC-703 in humans was absorbed rapidly from the gastrointestinal tract to the general circulation, ka = 1.21 hr-1, half-time of absorption was 0.65 hg (39 min). The volume of distribution of absorbed SPC-703 Vd/F was 10.1 l.