Mutagenic and carcinogenic effects of vinyl chloride monomers in humans
Fucić, A.; Horvat, D.; Dimitrović, B.
Arhiv za Higijenu Rada i Toksikologiju 42(1): 65-72
1991
ISSN/ISBN: 0004-1254 PMID: 1854267 Document Number: 384785
The use of vinyl chloride monomer in industry dates back to the late 1930s. Today the number of occupationally exposed industrial workers is estimated to be several million. After the first described cases of cancer among workers exposed to high concentrations of this gas, extensive research was initiated into possible mechanism of action on the living organism. This paper is a review of some current knowledge about the action of vinyl chloride monomer as a substance which after metabolic activation in the organism becomes a strong carcinogenic and mutagenic agent.