Mass spectrometric identification of DL-verapamil metabolites
Remberg, G.; Ende, M.; Eichelbaum, M.; Schomerus, M.
Arzneimittel-Forschung 30(3): 398-401
1980
ISSN/ISBN: 0004-4172 PMID: 7387749 Document Number: 155688
DL-verapamil [2,8-bis(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile; Isoptin] is metabolized in man by N-dealkylation -- mainly by cleavage of the N6-C7 bond -- and by demethylation of the methoxy groups. After oral administration, besides unchanged verapamil, 12 metabolites could be isolated from urine and their structures were elucidated by (GC-) mass spectrometry.
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