Identification of metabolites of arbidol by ultra-high performance liquid chromatography tandem mass spectrometry
Liu, X.; Li, H.; Bi, K.-S.; Chen, X.-H.; Cai, H.; Cai, B.-C.
Yao Xue Xue Bao 47(11): 1521-1526
2012
ISSN/ISBN: 0513-4870 PMID: 23387087 Document Number: 663540
UPLC-MS-MS system was used for the identification of arbidol metabolites in the rat feces, urine and plasma samples. The system was so powerful a way with high ability of separation and analysis, based on both chromatography and mass properties. The isotope of Br was also a good indicator for metabolites finding. There were altogether 9 metabolites detected and identified, including 2 phase I biotransformation products and 7 phase II ones. It is concluded that arbidol mainly undergo metabolic reactions such as N-demethylation, S-oxidation, glucuronidation and sulfation in rats.