Increased resistance of (CBAxC57BL/6) Fl hybrids to the graft-versus-host reaction during spleen regeneration
Meshkova, R.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 88(11): 587-589
1979
ISSN/ISBN: 0365-9615 PMID: 44208 Document Number: 145488
Partial splenectomy was performed in CBAXXC57BL/6/F1 hybrids 2, 12, 15 and 20 days before the graft-versus-host reaction induction (GVHR) and 2, 10 days after administration of parenteral immunocompentent cells. The recipients with the intact spleen or complete splenectomy and sham operated recipients served as control. Hybrids with the regenerating spleen were more resistant to GVHR within 12 days of regeneration, while splenectomy increased hybrid resistance to GVHR only when performed 2 days before or 2 days following the GVHR induction.