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Suppression of xenogeneic local graft versus host reaction by rat fetal spleen cells

Skowron-Cendrzak, A.; Rybczyńska, Z.; Sajak, A.; Dobrowolski, Z.

Archivum Immunologiae et Therapiae Experimentalis 32(4): 443-446

1984

ISSN/ISBN: 0004-069X
PMID: 6534317
Document Number: 229385
Xenogeneic local graft versus host reaction was induced by the injection of 5 X 10(7) adult rat spleen cells under the capsule of cyclophosphamide-treated adult mice. A significant decrease in the reaction, measured by the kidney enlargement index, was obtained by adding to the reacting cells 5-20% of fetal rat spleen cells. Fetal rat thymocytes of fetal mouse splenocytes were not found to be inhibitory. The suppressive activity of rat spleen cells waned completely on day 3 of the postnatal life.

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