Pretreatment with antilymphocyte globulin and donor cells on graft prolongation in an experimental model and some observations on graft-versus-host reaction

Pegrum, G.D.; Williams, G.; Markwick, J.; Barnes, R.M.

Postgraduate Medical Journal 52(5 Suppl): 47-50

1976


ISSN/ISBN: 0032-5473
PMID: 11454
Document Number: 99492
Survival of Lewis X Brown Norway F1 renal allografts was prolonged in Lewis recipients by pretreatment with small numbers of donor marrow cells and low dose antilymphocyte globulin(ALG)in combination. Either marrow cells or ALG alone were ineffective at these doses. It was also shown that pretreatment with marrow cells and antilymphocyte serum (ALS) considerably suppressed the local graft-versus-host reaction.

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