The mediation of the localization of polymorphonuclear leucocytes in glomeruli during the autologous phase of nephrotoxic nephritis
Sindrey, M.; Naish, P.
Clinical and Experimental Immunology 35(3): 350-355
1979
ISSN/ISBN: 0009-9104 PMID: 455777 Document Number: 141473
A passive model of the autologous phase of nephrotoxic nephritis (NTN) in rabbits was developed to study the events at the initiation of this stage of the disease. I.v. injection of sheep anti-rabbit glomerular basement membrane antiserum was followed 48 h later by 125I trace labeled rabbit anti-sheep IgG. Animals were killed 3 h after the 2nd antibody injection. Experiments were undertaken to investigate whether or not a reaction between the passive antibody Fc piece and polymorphonuclear leukocyte (PMN) Fc receptor occurred, causing the localization of PMN in glomeruli in the autologous phase of NTN. Such a reaction is apparently an important, but not exclusive, factor in glomerular PMN localization. The complement independence of the localization was confirmed. It appeared that PMN-dependent intraglomerular fibrin deposition was mediated exclusively by a reaction between antibody Fc piece and PMN Fc receptor.