Immune complexes in peripheral blood polymorphonuclear leucocytes of malignant melanoma patients
The, T.H.; van der Giessen, M.; Huiges, H.A.; Schraffordt Koops, H.; van Wingerden, I.
Clinical and Experimental Immunology 32(3): 387-391
1978
ISSN/ISBN: 0009-9104 PMID: 688694 Document Number: 125945
Immune complexes in PMN G and complement inclusions. Group (a), consisting of 34 patients free from tumor after surgical therapy, showed a median IgG score of 17, which was not statistically different from the control group (n = 11), with a median score of 10. The tumor-bearing group (b) (n = 31) showed a significnatly higher median score of 22. When group (a) was subdivided, patients who had an invasive growing melanoma with a bad prognosis (n =11) showed a significantly higher median score of 25, while the patients who had a superficial melanoma with good prognosis were not different from the controls. After subdividing group (b), patients with localized disease (n = 13) had a median score of 12, which was not different from that of the controls. The patients with regional lymph node involvement (n = 9) or distant metastases (n = 9) showed significantly higher median scores of 69 and 24, respectively. Six of 16 patients showed a significant drop in PMN inclusions after surgery. Complement scores gave similar patterns.