Similarity in the aldehyde oxidases from guinea-pig liver and polymorphonuclear leucocytes
Beedham, C.
Journal of Pharmacy and Pharmacology 38(1): 57-58
1986
ISSN/ISBN: 0022-3573 PMID: 2869129 Document Number: 275110
Partially purified enzyme from guinea-pig leucocytes has been shown to have properties similar to both guinea-pig and rabbit liver aldehyde oxidase. The presence of molybdenum in the leucocyte enzyme has been demonstrated and substrate oxidatoin by either guinea-pig enzyme was found to be completely inhibited by menadione, a potent inhibitor of rabbit liver aldehyde oxidase. The leucocyte enzyme resembles the guinea-pig liver enzyme in terms of substrate specificity but there is considerable variation in substrate oxidation rates between the two species.