Effect of lithium oxybutyrate on the polypeptide and noradrenaline content in the rat hypothalamus
Arefolov, V.A.; Iavorskiĭ, A.N.; Malikova, L.A.
Farmakologiia i Toksikologiia 42(3): 208-212
1979
ISSN/ISBN: 0014-8318 PMID: 446697 Document Number: 141398
It was established that single administration to rats of 200 mg/kg of lithium hydroxybutyrate releases noradrenalin from the terminals of hypothalamus adrenergic fibers and increases output of polypeptides in the neurons of supraoptic and paraventricular nuclei of the hypothalamus. After repeated administration of the drug (200 mg/kg) once a day over 6 days) the nuclei showed depressed output of polypeptides.
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