Dynamics of carrageenin-induced inflammation after use of lithium oxybutyrate
Aleksandrov, P.N.; Speranskaia, T.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 106(8): 233-235
1988
ISSN/ISBN: 0365-9615 PMID: 3416061 Document Number: 314521
Lithium hydroxybutyrate (200 mg/kg) has been shown to depress the development of carrageenan inflammation. Subcutaneous drug injection in chronic inflammation of the mucous membrane in the hamster cheek pouch restored the blood flow, checked dilatation of the blood vessels, decreased their permeability and prevented necrosis of the mucous membranes. Subcutaneous drug injection depressed all the signs of both phases of acute inflammatory reaction in the rat hind foot and promoted preservation of the hind foot function. Therefore, lithium hydroxybutyrate may be an effective preparation for the treatment of inflammation.