The potentiating effect of propionyl carnitine on prostacycline prevention of thrombosis induced by endothelin (ET-1) and K-carrageenin
Bertelli, A.; Bertelli, A.A.E.; Giovannini, L.
Drugs under Experimental and Clinical Research 20(1): 7-11
1994
ISSN/ISBN: 0378-6501 PMID: 7924894 Document Number: 428754
The aim of the present experiments was to ascertain whether prostacycline could exercise a protective effect against the formation of thrombosis in the rat tail induced by endothelin and K-carrageenin and to compare the effect of prostacycline with that of carnitine and propionyl carnitine. Both prostacycline and propionyl carnitine exhibited a similar protective effect on this experimental model. A combined protective effect of prostacycline administered with carnitine was also observed and a possible interaction between these two substances is proposed.