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Effect of clofibrate on the polypeptide content of a purified fraction of rat liver peroxisomes

Antonenkov, V.D.; Pirozhkov, S.V.; Panchenko, L.F.

Biokhimiia 48(9): 1429-1436

1983

ISSN/ISBN: 0320-9725
PMID: 6626603
Document Number: 205572
The effects of the hypolipaemic agent clofibrate on rat liver peroxisomes and of its "ghosts" obtained by solubilization of peroxisomal matrix peptides were studied by Na-DS polyacrylamide gel electrophoresis. Clofibrate significantly altered the amount of some peroxisomal polypeptides which is correlated with its effect on the enzyme composition of these organelles. The possibility of identification of polypeptides in gels with subunits of some peroxisomal enzymes (catalase, urate oxidase, components of fatty acid beta-oxidation chain, etc.) is discussed.

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