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Effects of papaverine on the release and metabolism of dopamine in rat striatum

Cubeddu, L.; Hoffmann, I.S.; Paris, V.B.

Journal of Pharmacology and Experimental Therapeutics 209(1): 73-78

1979

ISSN/ISBN: 0022-3565
PMID: 85703
Document Number: 140049
Papaverine (30 and 100 .mu.M) enhanced the basal efflux of radioactive products from rat neostriatal tissue slices prelabeled with AMP (0.1 mM) and 1-methyl-3-isobutylxanthine (0.1 mM) did not affect the basal or the K+-mediated outflow of radioactive products. Pretreatment with both agents failed to modify papaverine effects on basal and K+-evoked outflow of total 3H. Apparently papaverine effects on dopamine release and metabolism are not related to cAMP accumulation. The possible relationships between an effect of a drug on storage vesicles (granular effect) and enhanced neurotransmitter release are discussed.

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