The sodium oxybutyrate and nooglutil correction of dopamine release in the striatum of prenatally alcoholized rat pups
Kovalev, G.I.; Budygin, E.A.; Gaĭnetdinov, R.R.; Kudrin, V.S.; Trofimov, S.S.; Ostrovskaia, R.U.
Biulleten' Eksperimental'noi Biologii i Meditsiny 116(7): 56-58
1993
ISSN/ISBN: 0365-9615 PMID: 8400184 Document Number: 413305
The influence of prenatal exposure to ethanol on endogenous Dopamine (DA) release from perfused isolated striata of 20-day-old rats was studied, as well as its correction by nootropic drugs: sodium hydroxy butyrate and nooglutil. Administration of 20% ethanol per os at a daily dose of 5 mg per kg during the entire period of pregnancy led to a significant decrease in basal and K(+)-evoked DA efflux. Hydroxy-butyrate and Nooglutil (50 and 25 mg per kg, subcutaneously, daily from the 8th to the 20th day of life) normalized these alterations in alcohol-exposed neonates, although their effects on the offsprings of non-alcoholized rats were opposite. The probable neurochemical targets of ethanol and nootropics are discussed.