Effects of striatum stimulation and micro-iontophoretically applied dopamine and acetylcholine on the neuronal activity of the globus pallidus
Böttger, G.; Schmidt, J.
Acta Biologica et Medica Germanica 39(1): 123-131
1980
ISSN/ISBN: 0001-5318 PMID: 7424330 Document Number: 162964
Alert, myorelaxed rats were used to study the influence of electrical stimulation of the stiatum and micro-iontophoretic application of dopamine and acetylcholine upon the discharge activity of neurons of the Globus pallidus. Out of 55 pallidal neurons, 25 responded to striatum stimulation with an initial inhibition and subsequent irritation, and 21 with an irritation-inhibition sequence. 40% of the neurons were dopamine-sensitive (23% irritation, 77% inhibition) and 38% choline-sensitive (63% inhibition, 37% irritation). 25% of the dopamine-sensitive neurons were at the same time choline-sensitive. There was no direct relation demonstrable between the effects of striatum stimulation and micro-iontophoretic application of acetylcholine or dopamine.