Influence of x-ray irradiation on the effects of apomorphine and L-dopa with respect to the dopamine level in rat brain and corpus striatum
Markovska, V.; Georgiev, V.; Ankov, V.
Acta Physiologica et Pharmacologica Bulgarica 5(4): 27-34
1979
ISSN/ISBN: 0323-9950 PMID: 543408 Document Number: 143851
The influence of X-ray irradiation on the dopamine level in brain and in corpus striatum of male albino rats is studied. The changes in the influence of the dopaminergic agonists apomorphine and L-DOPA, applied independently and in combination, on the dopamine level in brain and striatum, are established comparatively (in non-irradiated rats and in rats on the 72nd hour after irradiation with 900 R). Apomorphine is found to have no significant influence on the dopamine level in brain and striatum of non-irradiated rats, while L-DOPA and its combination with apomorphine raise this level. On the 72nd hour after irradiation with 900 R there is no essential change in the dopamine level in brain and the striatum; apomorphine raises the dopamine level in brain and striatum; the effect of L-DOPA and its combination with apomorphine is potentiated with respect to the increase of the dopamine level in brain and striatum.