Effects of D-5-hydroxytryptophan and D-DOPA on binding at serotonin and dopamine receptors
Acton, G.
Research Communications in Chemical Pathology and Pharmacology 60(1): 129-132
1988
ISSN/ISBN: 0034-5164 PMID: 3132733 Document Number: 314734
Binding of the D-amino acids D-5-hydroxytryptophan (D-5-HTP) and D-dihydroxyphenylalanine (D-DOPA) to high affinity sites for serotonin (5-HT) and dopamine (DA) was studied in bovine striatum. D-5-HT bound to the 5-HT site with affinity in the micromolar range, but showed no appreciable binding at the DA site. D-DOPA showed little binding to either 5-HT or DA receptors.
Document emailed within 1 workday
Related Documents
Beramendi, V.; Alpert, M.; Guimón, J.; Friedhoff, A.; Gutiérrez, M. 1980: Controlled study of L-dopa in schizophrenia with reference to the theory of hypersensitivity of dopamine receptors Archivos de Neurobiologia 43(2): 107-124Berzétei, I.P.; Bagdy, E.; Hardy, M.; Borsy, J. 1985: The effect of GYKI-32 887 on dopamine (D2) and serotonin (5-HT1 and 5-HT2) receptors Polish Journal of Pharmacology and Pharmacy 37(3): 237-242
Molina-Holgado, E.; Dewar, K.M.; Descarries, L.; Reader, T.A. 1994: Altered dopamine and serotonin metabolism in the dopamine-denervated and serotonin-hyperinnervated neostriatum of adult rat after neonatal 6-hydroxydopamine Journal of Pharmacology and Experimental Therapeutics 270(2): 713-721
Hösli, L.; Hösli, E. 1987: Receptors for dopamine and serotonin on astrocytes of cultured rat central nervous system Journal de Physiologie 82(4): 191-195
Katzman, R.; Makman, M.H.; Ahn, H.S.; Mishra, R.K.; Gardner, E. 1977: Effects of drugs and lesions on dopamine-stimulated adenylate cyclase: evidence for different classes of dopamine receptors Transactions of the American Neurological Association 102: 76-79
Criswell, H.E.; Mueller, R.A.; Breese, G.R. 1992: Pharmacologic evaluation of SCH-39166, A-69024, NO-0756, and SCH-23390 in neonatal-6-OHDA-lesioned rats. Further evidence that self-mutilatory behavior induced by L-dopa is related to D1 dopamine receptors Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 7(2): 95-103
Levant, B.; Grigoriadis, D.E.; DeSouza, E.B. 1992: Characterization of [3H]quinpirole binding to D2-like dopamine receptors in rat brain Journal of Pharmacology and Experimental Therapeutics 262(3): 929-935
Kilpatrick, G.J.; el Tayar, N.; Van de Waterbeemd, H.; Jenner, P.; Testa, B.; Marsden, C.D. 1986: The thermodynamics of agonist and antagonist binding to dopamine D-2 receptors Molecular Pharmacology 30(3): 226-234
Koźniewska, E.; Samaan, A.H.; Skolasińska, K. 1978: Cerebrovascular response to intracarotid infusion of 5-hydroxytryptophan and L-DOPA in cats Archives Internationales de Pharmacodynamie et de Therapie 233(2): 281-289
Creese, I.; Sibley, D.R.; Leff, S.E. 1984: Agonist interactions with dopamine receptors: focus on radioligand-binding studies Federation Proceedings 43(13): 2779-2784
Heltzel, J.A.; Vogel, W.H. 1983: The distribution of serotonin binding sites: a comparison of 3H-serotonin binding in membrane preparations of rat gut and rat brain Advances in Biochemical Psychopharmacology 37: 385-394
Hoffmann, I.S.; Talmaciu, R.K.; Cubeddu, L.X. 1986: Interactions between endogenous dopamine and dopamine agonists at release modulatory receptors: multiple effects of neuronal uptake inhibitors on transmitter release Journal of Pharmacology and Experimental Therapeutics 238(2): 437-446
Rogue, P.; Zwiller, J.; Malviya, A.N.; Vincendon, G. 1990: Phosphorylation by protein kinase C modulates agonist binding to striatal dopamine D2 receptors Biochemistry International 22(3): 575-582
Markovska, V.; Georgiev, V.; Ankov, V. 1979: Influence of x-ray irradiation on the effects of apomorphine and L-dopa with respect to the dopamine level in rat brain and corpus striatum Acta Physiologica et Pharmacologica Bulgarica 5(4): 27-34
Burt, D.R.; Creese, I.; Snyder, S.H. 1976: Binding interactions of lysergic acid diethylamide and related agents with dopamine receptors in the brain Molecular Pharmacology 12(4): 631-638
Horn, A.S. 1977: Chemical, pharmacological and biochemical aspects of clomipramine. the binding of inhibitors of serotonin uptake to biological receptors Postgraduate Medical Journal 53(Suppl 4): 9-13
Severson, J.A.; Randall, P.K. 1985: D-2 dopamine receptors in aging mouse striatum: determination of high- and low-affinity agonist binding sites Journal of Pharmacology and Experimental Therapeutics 233(2): 361-368
White, F.J.; Appel, J.B. 1982: The role of dopamine and serotonin in the discriminative stimulus effects of lisuride Journal of Pharmacology and Experimental Therapeutics 221(2): 421-427
Lun, A.; Szuecz, L.; Gross, J.; Horvath, G.; Nagy, I. 1989: Effect of mild postnatal hypoxia and L-dopa administration on dopamine concentration in striata of the newborn rat and long term sequelae on dopamine turnover Biomedica Biochimica Acta 48(2-3): S231-S236
Soulairac, A.; Lambinet, H. 1988: Clinical studies of the effect of the serotonin precursor, L-5-hydroxytryptophan, on sleep disorders Schweizerische Rundschau für Medizin Praxis 77(34a): 19-23