Cerebrovascular response to intracarotid infusion of 5-hydroxytryptophan and L-DOPA in cats
Koźniewska, E.; Samaan, A.H.; Skolasińska, K.
Archives Internationales de Pharmacodynamie et de Therapie 233(2): 281-289
1978
ISSN/ISBN: 0003-9780 PMID: 308358 Document Number: 124947
Intracarotid administration of 5-hydroxytryptophan (10 mg/kg) results in a slight vasoconstriction of cerebral vessels. L-DOPA (20 mg/kg) administered by the same route enhances cerebral blood flow. The effect on cerebral blood flow of L-DOPA (20 mg/kg) following intracarotid 5-hydroxytryptophan (10 mg/kg) administration shows a potentiation of cerebral blood flow response in non-pretreated as well as in nialamide- and reserpine-pretreated cats.