Phosphorylation by protein kinase C modulates agonist binding to striatal dopamine D2 receptors
Rogue, P.; Zwiller, J.; Malviya, A.N.; Vincendon, G.
Biochemistry International 22(3): 575-582
1990
ISSN/ISBN: 0158-5231 PMID: 1981673 Document Number: 359561
The effect of purified protein kinase C (PKC) on dopamine D2 receptor binding was studied. Saturation binding with [3H]spiperone was not affected. In competition experiments using agonists PKC-treated membranes showed a significant reduction in the proportion of high affinity sites, and the influence of GTP.gamma.S was abolished. These results suggest that PKC-dependent mechanisms can regulate the coupling between the dopamine D2 receptor and its G-protein.
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