Stereotyped behaviour and striatal dopamine receptors in albino rat and the desert rat (Mastomys natalensis) : a comparative study
Gulati, A.; Srimal, R.C.; Dhawan, B.N.
Indian Journal of Experimental Biology 24(4): 248-251
1986
ISSN/ISBN: 0019-5189 PMID: 3770814 Document Number: 277454
Apomorphine and amphetamine induced stereotyped behaviour in albino and desert rat in a dose-related manner. For producing a comparable effect, however, a higher dose of both agents had to be used in desert rat. The stereotypy could be blocked by haloperidol but not by yohimbine. GBR 12909, a dopamine uptake inhibitor, potentiated the effect of threshold doses of apomorphine and amphetamine in both the species. Receptor binding studies with 3H-spiroperidol in corpus striatum indicate that the weaker potency of apomorphine and amphetamine in desert rat may be due to a lower affinity of its striatal dopamine receptors in comparison to albino rat.