Top Abstract Purchase Related
Home
>
Node
>
Subnode

Disruption of the Ca++ transport enzyme system in sarcoplasmic reticulum membranes upon exposure to phospholipid hydroperoxides and fatty acid hydroperoxides

Kagan, V.E.; Churakova, T.D.; Karagodin, V.P.; Arkhipenko, I.V.; Bilenko, M.V.

Biulleten' Eksperimental'noi Biologii i Meditsiny 87(2): 145-149

1979

ISSN/ISBN: 0365-9615
PMID: 154351
Document Number: 139464
It was shown that when injected into a suspension of sarcoplasmic reticulum (SR) vesicles phosphatidyl ethanol-amine hydroperoxide (HP) slightly activated Ca++-dependent ATPase and increased the permeability of SR membranes for Ca++ during the enzyme function. Linoleic acid HP had no effect on the parameters of the enzymatic Ca++- transporting system (activity of Ca++-dependent ATPase, Ca/ATP ratio, rate of Ca++ efflux) in the SR membranes due to its insufficient incorporation into the SR fragments. It is concluded that among the primary molecular products of lipid peroxidation (free fatty acid HP, phospholipid HP) induced both in vitro (by the Fe++ + ascorbate system) and in vivo (ischemia, E-avitaminosis), only the phospholipid HPs were modifiers of Ca++ transport in the SR membranes.

Document emailed within 1 workday
Secure & encrypted payments

Kagan, V.E.; Arkhipenko, I.V.; Kozlov, I.P. 1983: Modification of the enzyme system for Ca2+ transport in sarcoplasmic reticulum membranes during lipid peroxidation. Changes in the chemical composition and ultrastructural organization of the membranes Biokhimiia 48(1): 158-166
Gubskiĭ, I.I.; Zadorina, O.V.; Fedorov, A.N.; Bogdanova, L.A. 1991: Peroxide modification of skeletal muscle sarcoplasmic reticulum in antioxidant deficiency and under the action of ionol. I. Calcium transport into sarcoplasmic reticulum membranes Ukrainskii Biokhimicheskii Zhurnal 63(4): 81-87
Kulikov, V.I.; Lutsenko, M.T.; Kolesnikova, L.I.; Semeniuk, A.V.; Tseluĭko, S.S. 1980: Fatty acid hydroperoxides, fluorescent products, and tocopherol concentration in the tissues of rabbits exposed to cold Biulleten' Eksperimental'noi Biologii i Meditsiny 90(12): 681-682
Arkhipenko, I.U.; Gazdarov, A.K.; Kagan, V.E.; Kozlov, I.P.; Spirichev, V.B. 1976: Lipid peroxidation and disturbance in Ca2+ transport through sarcoplasmic reticulum membranes during E-avitaminosis Biokhimiia 41(10): 1898-1902
Tugaĭ, V.A.; Kurskiĭ, M.D.; Diadiusha, G.P.; Zakharchenko, A.N. 1990: The effect of pH on the passive transport of Ca2+ by membranes of fragmented sarcoplasmic reticulum of skeletal muscles Ukrainskii Biokhimicheskii Zhurnal 62(4): 67-71
Ritov, V.B. 1985: Blockers of the uncoupling action of caffeine on the Ca2+-transport function of sarcoplasmic reticulum membranes Biulleten' Eksperimental'noi Biologii i Meditsiny 99(4): 445-448
Chernysheva, G.V.; Iliushko, N.A.; Kondrat'ev, I.I.; Mel'nik, V.I.; Stoĭda, L.V. 1982: Effect of 30-day hypokinesia on Ca2+ transport, activity of ATPases and lipid peroxidation in the membranes of the sarcoplasmic reticulum and in the mitochondria of the skeletal and heart muscles Voprosy Meditsinskoi Khimii 28(6): 60-63
Sazontova, T.G.; Arkhipenko, I.V.; Meerson, F.Z. 1995: Adaptation to periodic hypoxia and diet with omega-3 polyunsaturated fatty acids increases the stability of myocardial sarcoplasmic reticulum Ca2+ transport to free radical oxidation Biulleten' Eksperimental'noi Biologii i Meditsiny 120(7): 42-45
Gazdarov, A.K.; Gazdarova, I.N. 1979: Polarographic determination of lipid hydroperoxides in the liver of guinea pigs on a varying allowance of ascorbic acid Voprosy Meditsinskoi Khimii 25(5): 524-527
Sazontova, T.G.; Belkina, L.M.; Siantsiun', F.; Meerson, F.Z. 1994: The Ca-transport system and damage to the sarcoplasmic reticulum membrane of the left ventricle in the rat during ischemia and reperfusion Biulleten' Eksperimental'noi Biologii i Meditsiny 117(2): 130-135
Klebanov, G.I.; Nikushkin, E.V.; Vladimirov, I.A. 1978: Phase transitions of model and biological membranes. II. Temperature-dependent structural reorganization of sarcoplasmic reticulum membranes Biofizika 23(2): 261-265
Holohan, P.D.; Pessah, N.I.; Pessah, I.N.; Ross, C.R. 1979: Reconstitution of N1-methylnicotinamide and p-aminohippuric acid transport in phospholipid vesicles with a protein fraction isolated from dog kidney membranes Molecular Pharmacology 16(1): 343-356
Klebanov, G.I.; Poglazov, A.F.; Nikushkin, E.V.; Shubin, M.V.; Rubtsov, B.V. 1979: Temperature-dependent functional changes in sarcoplasmic reticulum membranes Biofizika 24(4): 699-703
Moshkovskiĭ, I.S.; Tat'ianenko, L.V.; Nekrasova, N.A. 1983: Incorporation of synthetic phospholipids into the membranes of the sarcoplasmic reticulum from the rabbit muscle Molekuliarnaia Biologiia 17(2): 410-417
Ji, Y.; Zhao, M.; Qi, Y.; Dong, L.W.; Wu, L.L.; Peng, S.Q.; Su, J.Y. 1996: Effects of Arg-Gly-Asp-Ser on Ca2+ transport of myocardial sarcoplasmic reticulum in rat septic shock Zhongguo Yao Li Xue Bao 17(2): 129-132
Stoĭda, L.V. 1983: Change in the molecular properties of sarcoplasmic reticulum Ca-ATPase during modification of the membranes with cholesterol Biulleten' Eksperimental'noi Biologii i Meditsiny 96(10): 38-40
Kagan, V.E.; Azizova, O.A.; Arkhipenko, I.V.; Klaan, N.K.; Kozlov, I.P. 1977: Interrelationship between structural and functional modifications in the membranes of the sarcoplasmic reticulum following lipid peroxidation Biofizika 22(4): 625-630
Sabała, P.; Czarny, M.; Woronczak, J.P.; Barańska, J. 1993: Thapsigargin: potent inhibitor of Ca2+ transport ATP-ases of endoplasmic and sarcoplasmic reticulum Acta Biochimica Polonica 40(3): 309-319
Danylovych, I.V. 2007: Characteristics of passive Ca2+ -transport from cells of the myometrium sarcoplasmic reticulum in rats Fiziolohichnyi Zhurnal 53(1): 55-61
Babiy, A.V.; Gebicki, J.M. 1999: Decomposition of lipid hydroperoxides enhances the uptake of low density lipoprotein by macrophages Acta Biochimica Polonica 46(1): 31-42