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Neutralising effect of histone fractions from human leukocyte nuclei on heparin

Giannitsis, D.J.

Arzneimittel-Forschung 28(11): 2158-2159

1978

ISSN/ISBN: 0004-4172
PMID: 582923
Document Number: 138659
Histone fractions from human leukocyte nuclei can interact with heparin to form complexes measurable by means of laser nephelometry. Histone fractions have not all the same affinity to bound heparin and the lysinrich histone fraction cannot interact with heparin. The formation of histone/heparin complex depends not on the temperature between 20 degrees--37 degrees C or on the pH between 7--8.2. The precision of the method was estimated. The significance of the histones/heparin interactions for an assay method for control to the biological activity of heparin preparations and a possible biological role of these interactions in vivo was briefly discussed.

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Jelínek, R.; Horejsí, J.; Lostický, C.; Láznicka, M. 1976: Effect of histone on morphogenesis of chick embryonic constituents. III. the histone fractions Folia Morphologica 24(1): 68-72
Sipka, S.; Schröder, I.; Brazsnikova, N.A. 1987: Effect of different fractions of dialyzable leukocyte extract--transfer factor--on the chemiluminescence of human phagocytes Allergologia et Immunopathologia 15(3): 143-144
Bazzoni, G.; Beltrán Nuñez, A.; Mascellani, G.; Bianchini, P.; Dejana, E.; Del Maschio, A. 1993: Effect of heparin, dermatan sulfate, and related oligo-derivatives on human polymorphonuclear leukocyte functions Journal of Laboratory and Clinical Medicine 121(2): 268-275
Baxter, C.S.; Byvoet, P. 1974: Effects of carcinogens and other agents on histone methylation in rat liver nuclei by endogenous histone lysine methyltransferase Cancer Research 34(6): 1424-1428
Tiulenev, V.I.; Konoplich, L.A.; Rudenko, O.A. 1999: Effect of urea on proteolysis of histone H2A in calf thymus nuclei Ukrains'kyi Biokhimichnyi Zhurnal 71(2): 43-45
Teriukova, N.P.; Grandilevskaia, A.B.; Rozanov, I.M.; Ivanov, V.A. 2003: Effect of narrow fractions of chromatin non-histone proteins on the expression of membrane tumor-associated antigen MA-50 and phosphorylation of proteins of cultured rat hepatocytes Tsitologiia 45(3): 277-283
Barrowcliffe, T.W.; Le Shirley, Y. 1989: The effect of calcium chloride on anti-Xa activity of heparin and its molecular weight fractions Thrombosis and Haemostasis 62(3): 950-954
Takano, K.; Sasada, M.; Harakawa, N.; Nogawa, M.; Asagoe, K.; Yamamoto, K.; Okuma, M. 1997: Demonstration of functionally distinct human polymorphonuclear leukocyte fractions by simultaneous measurement of phagocytosis and oxygen radical generation International Journal of Hematology 66(1): 69-78
Saito, I.; Sugiyama, H.; Matsuura, T. 1982: Mechanism of DNA-histone crosslinks in UV-irradiated nuclei Nucleic Acids Symposium Series 11: 225-228
Tishchenko, L.I.; Miul'berg, A.A.; Ashmarin, I.P. 1971: Interrelations between histone acetylation and RNA synthesis in isolated nuclei Biokhimiia 36(3): 595-603
Yavin, E.J.; Eisenstein, M.; Fridkin, M. 1996: Binding pockets on the surface of human leukocyte elastase and human leukocyte cathepsin G. Implications to the design of inhibitors derived from human C-reactive protein Biomedical Peptides Proteins and Nucleic Acids: Structure Synthesis and Biological Activity 2(3): 71-78
Tkeshelashvili, L.K.; Sichinava, N.V.; Sapozhnikova, N.A.; Rcheulishvili, A.N. 1983: Ca2+, Mg2+, Zn2+ levels in histone fractions from normal and tumor cells Biofizika 28(4): 582-584
Gruenwedel, D.W.; Diaham, B. 1982: Methylmercury(II)-induced histone perturbations in nuclei isolated from calf thymus Molecular Pharmacology 22(1): 121-126
Markovski, S. 1977: Effect of heparin and its derivatives on the blood sugar level and blood lipid fractions in diabetes mellitus Vutreshni Bolesti 16(2): 87-94
Cremer, M.; Zinner, R.; Stein, S.; Albiez, H.; Wagler, B.; Cremer, C.; Cremer, T. 2004: Three dimensional analysis of histone methylation patterns in normal and tumor cell nuclei European Journal of Histochemistry: Ejh 48(1): 15-28
Eremeeva, V.V. 1971: Histone and DNA distribution in the process of formation of the chromatin substance of cerebral cortex neuron nuclei Arkhiv Anatomii Gistologii i Embriologii 60(2): 64-66
Giannitsis, D.J. 1978: Stimulatory effect of histone on glutathione reductase of human erythrocytes Arzneimittel-Forschung 28(2): 300-301
Okabe-Kado, J.; Honma, Y.; Hayashi, M.; Hozumi, M. 1981: Effects of histone fractions on induction of differentiation of cultured mouse myeloid leukemia cells Cancer Research 41(5): 1997-2002
White, M.M.; Siders, L.; Jennings, L.K.; White, F.L. 1992: The effect of residual heparin on the interpretation of heparin-induced platelet aggregation in the diagnosis of heparin-associated thrombocytopenia Thrombosis and Haemostasis 68(1): 88
Timofeev, I.V.; Kuznetsov, V.P.; Slavina, E.G.; Timofeeva, T.P.; Orlova, T.G. 1982: Effect of various forms of human leukocyte interferon on the natural killer activity of human lymphocytes Antibiotiki 27(10): 782-784