Effect of different fractions of dialyzable leukocyte extract--transfer factor--on the chemiluminescence of human phagocytes
Sipka, S.; Schröder, I.; Brazsnikova, N.A.
Allergologia et Immunopathologia 15(3): 143-144
1987
ISSN/ISBN: 0301-0546 PMID: 3661353 Document Number: 299813
The chemiluminescence (CL) inducing effect of the fractions of dialyzable leukocyte extract (DLE)--transfer factor--from tonsil leukocytes was tested on the phagocytes of human whole blood. The fractionation of DLE by Sephadex G-25 results in three main fractions: I, II, III. We found only fraction II having a direct CL inducing effect on the non-stimulated cells. Fraction II increased further the CL of phagocytes which were stimulated by zymosan (Mannozym). Fractions I and III were ineffective. We suggest that in the complex "transfer factor" effects of DLE, the stimulation of the peripheral phagocytes of blood-by the oligopeptides of fraction II may have an important role.