The effect of various organochlorine pesticides on the immunologic reactivity of the white rat
Giurgea, R.; Wittenberger, C.; Frecus, G.; Manciulea, S.; Borsa, M.; Coprean, D.; Ilyes, S.
Archiv für Experimentelle Veterinarmedizin 32(5): 769-774
1978
ISSN/ISBN: 0003-9055 PMID: 367308 Document Number: 138658
Wistar rats, aged 30 and 90 days, received Aldrin and Lindan treatment (8 ppm or 11 ppm) over 60 days, followed by inoculation of E. coli. The capacity of antibody formation was changed but not inhibited. Functional disorders occurred in the thymus (decline of nucleic acids), adrenal gland (decline of Vitamin C), and in the protein synthesis. The toxicity of even smaller Aldrin doses obviously was stronger than that of Lindan. The toxicity of either substance to younger animals was stronger than to individuals in more advanced age.