A pupillographical study on the presence of organochlorine pesticides in autonomic nerve disturbance
Shirakawa, S.; Ishikawa, S.; Miyata, M.; Rea, W.J.; Johnson, A.R.
Nippon Ganka Gakkai Zasshi 94(4): 418-423
1990
ISSN/ISBN: 0029-0203 PMID: 2396593 Document Number: 607
It is well known that the effect of organophaste pesticides on the autonomic nervous system is a cholinergic reaction. However no study has been done assessing the effect or organochlorine pesticides on the autonomic nervous system. We evaluated the autonomic nerve function using open-loop pupillography in 20 patients who had exposure to the organochlorine pesticides. Significant differences were seen in pupil are (p<.006), velocity of both constriction and dilatation (p<.001), and dilatation time (p<.02), when compared with 18 normal subjects. Autonomic nerve disturbances were detected in eighteen of 20 patients (90%) by evaluating the pupillary light reflex in each patient. Sympathetic nerve inhibition; i.e., sympatholytic pattern, was recognized in ten of 18 patient (55%). Four patients with sympatholytic pattern had a disturbance not only in the sympathetic nerve, but also parasympathetic nerve involvement suggesting pandysautonomia. The residue blood level of the organochlorine pesticides was examined in each patient. A high frequency of the DDE was recognized (85%). It was concluded that the toxicity of the organochlorine pesticide on the autonomic nerve appear as inhibitory effect on pupil light reflex.
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