Mechanism of DNA-histone crosslinks in UV-irradiated nuclei

Saito, I.; Sugiyama, H.; Matsuura, T.

Nucleic Acids Symposium Series 11: 225-228

1982


ISSN/ISBN: 0261-3166
PMID: 7183962
Document Number: 196735
Mechanism of the DNA-histone crosslinks in UV-irradiated chicken erythrocyte nuclei has been investigated. It has been demonstrated that the major chemical reaction induced by irradiation of DNA-histone complexes is the crosslinking between lysine and thymine residues and subsequent transfer of thyminyl group from DNA to lysine residues of histones.

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