Mechanism of the pyrazidol potentiation of the hyperglycemic effect of adrenaline
Egorova, E.F.; Liberman, S.S.
Farmakologiia i Toksikologiia 41(1): 36-40
1978
ISSN/ISBN: 0014-8318 PMID: 624387 Document Number: 137632
The effect of pyrazidol, a new tricyclic antidepressant, on the change in the activity of the phosphorylase in homogenates of the liver and heart, produced by epinephrine and cortisol, was studied. Information obtained in intact rats showed pyrazidol capable of potentiating the action of epinephrine, such effect being absent in adrenalectamized animals. The beta-adrenoblocking agent (propranolol) and the alpha-adrenoblocking agent (phentolamine) lower the activation of the phosphorylase called forth both by epinphrine and by the latter together with pyrazidol. In adrenalectomized rats phentolamine exerts against the background of the cortisol and pyrazidol action a more pronounced effect than does propranolol. These data suggest that one of the factors responsible for the potentiation of the antidepressant hyperglycemic action of epinephrine and cortisol is a greater intensity of glycogenolysis, coming as a result of the phosphorylase activation.