The effect of pyrazidol and inkazan on the rotation behavior of rats
Mashkovskiĭ, M.D.; Bogdanov, M.B.; Bondarenko, N.A.
Farmakologiia i Toksikologiia 52(6): 29-32
1989
ISSN/ISBN: 0014-8318 PMID: 2625142 Document Number: 338249
Effect of some MAO inhibitors on rotational behavior induced by d-amphetamine in unilaterally 6-OHDA-lesioned rats was studied. Among all MAO inhibitors tested only 1-deprenyl induced rotational behavior. Nialamide, chlorgiline, pyrazidol and inkazan dose-dependently enhanced rotational behavior induced by 2 mg/kg i. p. d-amphetamine and pargiline depressed it. Nialamide and inkazan greatly enhanced rotational behavior induced by 0.5 mg/kg i. p. d-amphetamine. It is suggested that nialamide and inkazan may have similar effects on DA-ergic neurotransmission.